Dileep Raveendran-Nair, Mechanical Engineer for Scaled-up Bioprocesses at Celignis.

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Background

Dileep Raveendran Nair is a Mechanical Engineer with over 11 years of hands-on experience in biofuel, biochar, and bioproduct process engineering. His career has focused on the operation, maintenance, and optimization of large-scale bioprocess and bioenergy systems, integrating engineering precision with biotechnological innovation to advance sustainable industrial application.

At Celignis Dileep is actively engaged in biochar production and biomass extraction projects, contributing to process development, pilot-scale operation, and optimization of biomass valorisation pathways. His work bridges mechanical systems and biological processes, supporting the development of efficient and scalable bioprocess solutions.

Dileep’s core expertise lies in fermentation process engineering, with extensive practical experience in cultivating bacterial, fungal, and yeast systems under both submerged and solid-state fermentation modes. He has successfully worked on the production of industrially significant biomolecules such as 1,3-propanediol (1,3-PDO), melanin, and poly-γ-glutamic acid (PGA). His strong foundation in reactor operation, process monitoring, and yield optimization has contributed to the development of efficient microbial bioprocesses.

Beyond industrial practice, Dileep has contributed to peer-reviewed international publications and a scientific conference presentation, demonstrating his active participation in research and knowledge dissemination. His work emphasizes innovation, precision, and sustainability in modern bioprocessing and renewable technology development.

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Expertise and Track-Record

Fermentation and Bioprocessing

Dileep has extensive experience in developing, optimizing, and scaling microbial fermentation processes involving bacterial, fungal, and yeast systems. His research and industrial work include fermentation strategies for producing 1,3-propanediol and melanin, as well as waste-to-value conversions. He is proficient in operating bioreactors up to 200 L scale and integrating fermentation with downstream purification systems.

Pilot Plant Maintenance and Troubleshooting

Dileep has managed Solid-State Fermentation (SSF) pilot facilities, including Koji rooms equipped with autoclaves, ultracentrifuges, humidity and temperature control systems, and laminar airflow setups. His preventive maintenance and systematic troubleshooting approaches ensure safe, consistent, and high-quality pilot-scale performance.

Scale-Up and Process Optimization

With strong analytical and mechanical expertise, Dileep specializes in mass and energy balance calculations, process scale-up, and efficiency optimization. He collaborates closely with interdisciplinary R&D teams to translate laboratory innovations into robust, sustainable industrial processes. His work focuses on enhancing productivity while minimizing operational energy and resource demands.

Process Operations and Equipment Handling

Dileep is adept in the operation, maintenance, and troubleshooting of diverse bioprocess and utility systems, including:

- High-pressure pretreatment reactor: 1000 L (helical impeller, direct steam injection, jacket circulation)

- Hydrolysis reactor: 500 L (paddle impeller, jacketed)

- Neutralization reactor: 750 L (paddle impeller)

- Fermenter: 200 L (150 L working volume)

- Distillation columns, filtration units, reverse osmosis systems, and continuous centrifuges

- Utility systems: Boilers (500 kg/hr steam), thermic fluid systems, chillers (2 TR), and cooling towers (40 TR)

Qualifications

Diploma in Mechanical Engineering (2014 – 2017) - Government Polytechnic College, Vattiyoorkavu, Thiruvananthapuram, Kerala, India

Vocational Higher Secondary Education – Refrigeration and Air Conditioning (2010 – 2012), Victory Vocational Higher Secondary School, Nemom, Thiruvananthapuram, Kerala, India

Publications

Rajesh, R.O., Shruthy, N.S., Akhila, S., Godan, T.K., Dileep, N.R., de Carvalho, J.C., de Souza Vandenberghe, L.P., (2023) Whole-cell synthesis of 2, 5-furandicarboxylic acid from pineapple waste under various fermentation strategies, Bioresource Technology 386: 129545

Click to read abstract

Link

2,5-Furandicarboxylic acid (FDCA) is one of the platform chemicals and monomers used in plastic industries, currently synthesized by carcinogenic and toxic chemical processes with high pressure and temperature. The aim of this study was to develop a bioprocess for the production of FDCA. 5-(Hydroxymethyl)furfural (HMF) was synthesized (22.67 � 1.36 g/l/h) from pineapple peel using chromium(III) chloride (CrCl3) at 100 �C. After optimization, approximately 3 mg/l/h FDCA was produced by Aspergillus flavus APLS-1 from HMF in a 2.5 L fermenter in a batch strategy. Parallel and immobilized packed bad bioreactors showed less production of FDCA. A fed-batch strategy produced 3.5 � 0.3 mg/l/h of FDCA in shake flasks. Also, approximately 0.55 mg/l/h of FDCA was produced from pineapple waste derived HMF. However, these bioprocesses may be improved to increase the yield of renewable FDCA, in the future. This is the first report on FDCA production from pineapple waste.

Celignis News Articles on Dileep

February 3rd 2025

Dileep Joins the Celignis Team

Will play a key role as our "Mechanical Engineer for Scaled-up Bioprocesses"

Today the Celignis family welcomed Dileep Raveendran-Nair to the fold. Dileep is a Mechanical Engineer with over 11 years of hands-on experience in biofuel, biochar, and bioproduct process engineering. His career has focused on the operation, maintenance, and optimization of large-scale bioprocess and bioenergy systems, integrating engineering precision with biotechnological innovation to advance sustainable industrial application.

At Celignis he will play a key-role ("Mechanical Engineer for Scaled-up Bioprocesses") in the development of our bioprocessing capabilities as we increase the Technology Readiness Levels (TRL) of our bioprocessing facility to TRL7 and cubic-metre reactors.

Dileep will be involved in the development and implementation of Bioprocess Development Services for our clients and in the scaled-up bioprocessing activities in our numerous ongoing research projects. Additionally, Dileep will take the lead in Celignis's Biochar Production services for our clients.

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