Downstream ProcessingDownstream-processing in bioprocesses concerns the ways in which output streams (e.g. solid, liquid, slurry etc.) are handled and the means for the recovery and purification of the targeted products. It is a crucial step in bioprocess development that is often overlooked, especially in early stages of research and development, where much of the focus tends to be on optimizing the bioconversion process itself. This is a critical oversight given that downstream processing can account for a large portion (sometimes up to 80%) of the total production costs, particularly in processes dealing with dilute concentrations of the target product or complex mixtures.
Importance in BioprocessesGiving due focus to downstream processing in bioprocess development can not only lead to better product recovery and quality but also to significant cost savings and improved sustainability. This is especially important in processes concerning the valorisation of lignocellulosic feedstocks, where the complexity of the feedstock and the need for high-purity end products can make the downstream process a significant factor in the overall economic viability of the process.
BackgroundA filter-dryer can be a key component in the downstream processing stages of a bioprocess. It combines the unit operations of solid-liquid separation and drying into a single piece of equipment.
Important Aspects in Filter-Dryers
Advantages of Filter-Dryers
Disadvantages of Filter-Dryers
Sweco PharmASep PH30 Filter-DryerSWECO PharmASep Filter-Dryers were designed for the aseptic batch filtration and washing of solids and for their further de-watering and drying.
Has a deep understanding of all biological and chemical aspects of bioproceses. Has developed Celignis into a renowned provider of bioprocess development services to a global network of clients.
A dynamic, purpose-driven chemical engineer with expertise in bioprocess development, process design, simulation and techno-economic analysis over several years in the bioeconomy sector.
PhD (Analytical Chemistry)
Dreamer and achiever. Took Celignis from a concept in a research project to being the bioeconomy's premier provider of analytical and bioprocessing expertise.