Downstream ProcessingDownstream-processing in bioprocesses concerns the ways in which output streams (e.g. solid, liquid, slurry etc.) are handled and the means for the recovery and purification of the targeted products. It is a crucial step in bioprocess development that is often overlooked, especially in early stages of research and development, where much of the focus tends to be on optimizing the bioconversion process itself. This is a critical oversight given that downstream processing can account for a large portion (sometimes up to 80%) of the total production costs, particularly in processes dealing with dilute concentrations of the target product or complex mixtures.
Importance in BioprocessesGiving due focus to downstream processing in bioprocess development can not only lead to better product recovery and quality but also to significant cost savings and improved sustainability. This is especially important in processes concerning the valorisation of lignocellulosic feedstocks, where the complexity of the feedstock and the need for high-purity end products can make the downstream process a significant factor in the overall economic viability of the process.
BackgroundDistillation is a separation technique that exploits differences in the boiling points of the components in a liquid mixture. It is widely used to purify products, concentrate solutions, or remove unwanted compounds in the bioprocessing industry. Examples of its applications include the separation of ethanol from fermentation broth in biofuel production, the isolation of essential oils in the food and flavor industry, and the purification of biochemicals and biopharmaceuticals.
Important Aspects in Distillation
Advantages of Distillation
Disadvantages of Distillation
Buchi R-205 Rotavapor SystemThe Buchi R-205 Rotavapor System is a high-end lab-scale rotary evaporator recognised for its flexibility and dependability. It has a rotation range from 20 to 280 rpm, an automatic height adjustment feature, and is designed to process samples ranging from 50 mL to 3 L. The system comprises the Buchi B-490 Heating Bath, glassware attachments, Buchi V-500 vacuum pump, and the V-800 vacuum controller.
Has a deep understanding of all biological and chemical aspects of bioproceses. Has developed Celignis into a renowned provider of bioprocess development services to a global network of clients.
A dynamic, purpose-driven chemical engineer with expertise in bioprocess development, process design, simulation and techno-economic analysis over several years in the bioeconomy sector.
PhD (Analytical Chemistry)
Dreamer and achiever. Took Celignis from a concept in a research project to being the bioeconomy's premier provider of analytical and bioprocessing expertise.